From The Free On-line Dictionary of Computing (8 July 2008) [foldoc]:
LISA
1. <computer> Local Integrated Software Architecture.
A personal computer introduced by Apple Computer, Inc. in
1983. The LISA was a predecessor of the Macintosh and was
the first personal computer on the market with a {graphical
user interface}.
It was origionally named after Steve Jobs's daughter. The
acronym was applied later.
[Spec?]
2. <tool> A system for statistical data analysis, similar to
S.
{FTP MIT (ftp://dolphin.mit.edu/)}.
3. <event> Large Installation Systems Administration.
(2001-10-16)